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KMID : 1036020160050020133
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지질.동맥경화학회지
2016 Volume.5 No. 2 p.133 ~ p.143
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Serum Lipid Level in HBsAg Carriers without a History of Hepatitis based on Nationwide Health and Nutrition Examination Datasets
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Koo Bo-Kyung
Moon Min-Kyong
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Abstract
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Objective: We investigated serum lipid levels in asymptomatic HBsAg carriers and the general population using the Korean National Health and Nutrition Examination Survey (KNHANES).
Methods: We analyzed the data of patients aged ≥30 years from the KNHANES 2007-2014 datasets. Subjects with diabetes mellitus, triglyceride levels >1000 mg/dL, a history of heavy alcohol consumption, or lipid-lowering medication were excluded. HBsAg carriers were divided into “unknown HBsAg carrier” and “known HBsAg carrier” according to previous self-recognition of HBsAg status using a questionnaire.
Results: Compared with control subjects (n=24,880; male 33.9%; mean age 52±14 years), HBsAg carriers (n=1,061; male 40.6%; mean age 50±13 years) showed significantly higher AST and ALT levels, lower platelet counts and higher body mass index (BMI) (all p<0.001). HBsAg carriers revealed lower total cholesterol, LDL cholesterol and triglyceride levels (all p<0.001) compared with control subjects, irrespective of previous awareness of HBsAg positivity. Hypertriglyceridemia and low HDL cholesterolemia were less prevalent even in the “unknown HBsAg carrier” group compared with control subjects [age, sex and BMI-adjusted odds ratio, 0.566 (95% confidence interval, 0.468-0.684) and 0.822 (0.708-0.956), respectively].
Conclusion: In conclusion, HBsAg carriers exhibited low total cholesterol, LDL cholesterol, and triglyceride levels compared with control subjects. Hypertriglyceridemia and low HDL cholesterolemia were also less frequently detected in HBsAg carriers even after adjustments for age, sex, and BMI.
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KEYWORD
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Cholesterol, Triglyceride, HDL cholesterol, Hepatitis B virus
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